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Infantile Hemangioma

MedGen UID:
1380698
•Concept ID:
C4317089
•
Neoplastic Process
Synonyms: Cellular Hemangioma; Infantile Hemangioendothelioma; Infantile hemangioma; Juvenile Capillary Hemangioma; Juvenile Hemangioma; Strawberry Nevus
SNOMED CT: Infantile hemangioma (1293125002)

Definition

A capillary hemangioma that may regress spontaneously. It occurs in infants and children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfantile Hemangioma

Professional guidelines

PubMed

Laser treatment of infantile hemangioma.
Ziad K, Badi J, Roaa Z, Emily AH
J Cosmet Dermatol 2023 Jun;22 Suppl 2:1-7. Epub 2023 Feb 12 doi: 10.1111/jocd.15671. PMID: 36774645
Infantile hemangioma. Part 2: Management.
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
PHACE Syndrome: Consensus-Derived Diagnosis and Care Recommendations.
Garzon MC, Epstein LG, Heyer GL, Frommelt PC, Orbach DB, Baylis AL, Blei F, Burrows PE, Chamlin SL, Chun RH, Hess CP, Joachim S, Johnson K, Kim W, Liang MG, Maheshwari M, McCoy GN, Metry DW, Monrad PA, Pope E, Powell J, Shwayder TA, Siegel DH, Tollefson MM, Vadivelu S, Lew SM, Frieden IJ, Drolet BA
J Pediatr 2016 Nov;178:24-33.e2. Epub 2016 Sep 19 doi: 10.1016/j.jpeds.2016.07.054. PMID: 27659028Free PMC Article

Recent clinical studies

Etiology

Infantile hemangioma. Part 2: Management.
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
PHACE Syndrome: Consensus-Derived Diagnosis and Care Recommendations.
Garzon MC, Epstein LG, Heyer GL, Frommelt PC, Orbach DB, Baylis AL, Blei F, Burrows PE, Chamlin SL, Chun RH, Hess CP, Joachim S, Johnson K, Kim W, Liang MG, Maheshwari M, McCoy GN, Metry DW, Monrad PA, Pope E, Powell J, Shwayder TA, Siegel DH, Tollefson MM, Vadivelu S, Lew SM, Frieden IJ, Drolet BA
J Pediatr 2016 Nov;178:24-33.e2. Epub 2016 Sep 19 doi: 10.1016/j.jpeds.2016.07.054. PMID: 27659028Free PMC Article
A randomized, controlled trial of oral propranolol in infantile hemangioma.
Léauté-Labrèze C, Hoeger P, Mazereeuw-Hautier J, Guibaud L, Baselga E, Posiunas G, Phillips RJ, Caceres H, Lopez Gutierrez JC, Ballona R, Friedlander SF, Powell J, Perek D, Metz B, Barbarot S, Maruani A, Szalai ZZ, Krol A, Boccara O, Foelster-Holst R, Febrer Bosch MI, Su J, Buckova H, Torrelo A, Cambazard F, Grantzow R, Wargon O, Wyrzykowski D, Roessler J, Bernabeu-Wittel J, Valencia AM, Przewratil P, Glick S, Pope E, Birchall N, Benjamin L, Mancini AJ, Vabres P, Souteyrand P, Frieden IJ, Berul CI, Mehta CR, Prey S, Boralevi F, Morgan CC, Heritier S, Delarue A, Voisard JJ
N Engl J Med 2015 Feb 19;372(8):735-46. doi: 10.1056/NEJMoa1404710. PMID: 25693013
Infantile hemangioma.
Holland KE, Drolet BA
Pediatr Clin North Am 2010 Oct;57(5):1069-83. Epub 2010 Aug 21 doi: 10.1016/j.pcl.2010.07.008. PMID: 20888458

Diagnosis

Vascular Lesions.
Urban MJ, Williams EF 3rd
Facial Plast Surg Clin North Am 2024 Feb;32(1):13-25. Epub 2023 Oct 21 doi: 10.1016/j.fsc.2023.09.003. PMID: 37981409
Infantile hemangioma. Part 1: Epidemiology, pathogenesis, clinical presentation and assessment.
Rodríguez Bandera AI, Sebaratnam DF, Wargon O, Wong LF
J Am Acad Dermatol 2021 Dec;85(6):1379-1392. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.019. PMID: 34419524
Infantile hemangioma. Part 2: Management.
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
PHACE Syndrome: Consensus-Derived Diagnosis and Care Recommendations.
Garzon MC, Epstein LG, Heyer GL, Frommelt PC, Orbach DB, Baylis AL, Blei F, Burrows PE, Chamlin SL, Chun RH, Hess CP, Joachim S, Johnson K, Kim W, Liang MG, Maheshwari M, McCoy GN, Metry DW, Monrad PA, Pope E, Powell J, Shwayder TA, Siegel DH, Tollefson MM, Vadivelu S, Lew SM, Frieden IJ, Drolet BA
J Pediatr 2016 Nov;178:24-33.e2. Epub 2016 Sep 19 doi: 10.1016/j.jpeds.2016.07.054. PMID: 27659028Free PMC Article

Therapy

Infantile Hemangiomas.
Hasbani DJ, Hamie L
Dermatol Clin 2022 Oct;40(4):383-392. Epub 2022 Sep 16 doi: 10.1016/j.det.2022.06.004. PMID: 36243426
Noninferiority and Safety of Nadolol vs Propranolol in Infants With Infantile Hemangioma: A Randomized Clinical Trial.
Pope E, Lara-Corrales I, Sibbald C, Liy-Wong C, Kanigsberg N, Drolet B, Ma J
JAMA Pediatr 2022 Jan 1;176(1):34-41. doi: 10.1001/jamapediatrics.2021.4565. PMID: 34747977Free PMC Article
Infantile hemangioma. Part 2: Management.
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
A randomized, controlled trial of oral propranolol in infantile hemangioma.
Léauté-Labrèze C, Hoeger P, Mazereeuw-Hautier J, Guibaud L, Baselga E, Posiunas G, Phillips RJ, Caceres H, Lopez Gutierrez JC, Ballona R, Friedlander SF, Powell J, Perek D, Metz B, Barbarot S, Maruani A, Szalai ZZ, Krol A, Boccara O, Foelster-Holst R, Febrer Bosch MI, Su J, Buckova H, Torrelo A, Cambazard F, Grantzow R, Wargon O, Wyrzykowski D, Roessler J, Bernabeu-Wittel J, Valencia AM, Przewratil P, Glick S, Pope E, Birchall N, Benjamin L, Mancini AJ, Vabres P, Souteyrand P, Frieden IJ, Berul CI, Mehta CR, Prey S, Boralevi F, Morgan CC, Heritier S, Delarue A, Voisard JJ
N Engl J Med 2015 Feb 19;372(8):735-46. doi: 10.1056/NEJMoa1404710. PMID: 25693013

Prognosis

Laser treatment of infantile hemangioma.
Ziad K, Badi J, Roaa Z, Emily AH
J Cosmet Dermatol 2023 Jun;22 Suppl 2:1-7. Epub 2023 Feb 12 doi: 10.1111/jocd.15671. PMID: 36774645
Infantile Hemangioma: A Current Review.
Pahl KS, McLean TW
J Pediatr Hematol Oncol 2022 Mar 1;44(2):31-39. doi: 10.1097/MPH.0000000000002384. PMID: 34966091
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
Guidance Document for Hepatic Hemangioma (Infantile and Congenital) Evaluation and Monitoring.
Iacobas I, Phung TL, Adams DM, Trenor CC 3rd, Blei F, Fishman DS, Hammill A, Masand PM, Fishman SJ
J Pediatr 2018 Dec;203:294-300.e2. Epub 2018 Sep 21 doi: 10.1016/j.jpeds.2018.08.012. PMID: 30244993
Infantile hemangioma.
Holland KE, Drolet BA
Pediatr Clin North Am 2010 Oct;57(5):1069-83. Epub 2010 Aug 21 doi: 10.1016/j.pcl.2010.07.008. PMID: 20888458

Clinical prediction guides

Medical Management of Infantile Hemangiomas: An Update.
Colmant C, Powell J
Paediatr Drugs 2022 Jan;24(1):29-43. Epub 2021 Oct 22 doi: 10.1007/s40272-021-00477-9. PMID: 34677814
Efficacy and Safety of Topical Timolol for the Treatment of Infantile Hemangioma in the Early Proliferative Stage: A Randomized Clinical Trial.
Muñoz-Garza FZ, Ríos M, Roé-Crespo E, Bernabeu-Wittel J, Montserrat-García MT, Puig L, Gich I, Baselga E
JAMA Dermatol 2021 May 1;157(5):583-587. doi: 10.1001/jamadermatol.2021.0596. PMID: 33825828Free PMC Article
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
Infantile hemangiomas: current management.
Hochman M
Facial Plast Surg Clin North Am 2014 Nov;22(4):509-21. Epub 2014 Aug 21 doi: 10.1016/j.fsc.2014.07.003. PMID: 25444725
Infantile hemangioma.
Holland KE, Drolet BA
Pediatr Clin North Am 2010 Oct;57(5):1069-83. Epub 2010 Aug 21 doi: 10.1016/j.pcl.2010.07.008. PMID: 20888458

Recent systematic reviews

The prevalence, complications, and risk factors for infantile hemangioma: a systematic review and meta-analysis.
Sun Y, Zhao J, Meng Y, Luo X, Jiang C, Deng G, Lei S
Int J Dermatol 2024 Jun;63(6):737-746. Epub 2024 Feb 8 doi: 10.1111/ijd.17062. PMID: 38329175
Skin sequelae in patients with infantile hemangioma: a systematic review.
Li W, Kang J, Bai S, Yuan L, Liu J, Bi Y, Sun J, He Y
Eur J Pediatr 2023 Feb;182(2):479-488. Epub 2022 Nov 24 doi: 10.1007/s00431-022-04688-1. PMID: 36434402
Sirolimus for diffuse intestinal infantile hemangioma with PHACE features: systematic review.
Kleinman EP, Blei F, Adams D, Greenberger S
Pediatr Res 2023 May;93(6):1470-1479. Epub 2022 Sep 30 doi: 10.1038/s41390-022-02325-z. PMID: 36180586
Propranolol Therapy in Infantile Hemangioma: It Is Not Just About the Beta.
Lee JC, Modiri O, England RW, Shawber CJ, Wu JK
Plast Reconstr Surg 2021 Apr 1;147(4):875-885. doi: 10.1097/PRS.0000000000007699. PMID: 33776033
Laser treatment of infantile hemangioma: A systematic review.
Chinnadurai S, Sathe NA, Surawicz T
Lasers Surg Med 2016 Mar;48(3):221-33. Epub 2015 Dec 29 doi: 10.1002/lsm.22455. PMID: 26711436

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